Does Plasma Fibrinogens and C-reactive Protien Predicts the Incidence of Myocardial Infraction in Patients with Normal Lipids Profile?

Objectives: To evaluate plasma fibrinogen and C-reactive proteins in patients with acute myocardial infarction (AMI) and compare it with normal lipid profile in healthy controls. Methodology: Plasma fibrinogen and C-reactive proteins were determined in 165 patients and 165 age –sex matched control. The plasma fibrinogen was determined using kit, which was obtained from TECO GmbH, Dieselstr. 1, 84088 Neufahrn NB. The C-reactive protein were determined using high sensitivity enzyme Immunoassay kit manufactured by Life Diagnostics, inc. Also lipid profile was analysed enzymatically in these subjects. The values were expressed as means ± standard deviation (SD) and data from patients and controls was compared using student “t” test. Results: Serum CRP and Plasma Fibrinogen were increased significantly (p<0.001) in AMI subjects compared to controls. High fibrinogen concentration and C-Reactive proteins seem to be important contributory risk factor in Indian CAD patients. Conclusions: Thrombotic and inflammatory markers in combination may contribute to AMI with increased severity of the disease. Further larger studies on a nationwide basis recruiting a large number of AMI patients should be done to substantiate these findings.